Prof. Nyasha Chin’ombe

Qualifications:

PhD in Medical Microbiology (UCT), MSc in Biotechnology (UZ), BSc in Biological Sciences (UZ)

Academic Appointments:

Research Interests:

Faculty: College of Health Science

Department:

Research Category: Health and Medicine

Biography:

Email:

Phone:

Publications:

1. Dube Mandishora RS, Gjøtterud KS, Lagström S, Stray-Pedersen B, Duri K, Chin'ombe N, Nygård M, Christiansen IK, Ambur OH, Chirenje MZ, Rounge TB. Intra-host sequence variability in human papillomavirus. Papillomavirus Res. 2018. 5:180-191.
2. Manjeese W, Muzividzi B, Mbanga J, Mufandaedza J, Chin’ombe N. RpoB Gene-Based Characterization of Non-Tuberculous Mycobacteria in Zimbabwe. Journal of Advances in Microbiology. 2017: 6(1): 2456-7116.
3. Dube-Mandishora RS, Christiansen IK, Chin'ombe N, Duri K, Ngara B, Rounge TB, Meisal R, Ambur OH, Palefsky JM, Stray-Pedersen B, Chirenje ZM. Genotypic diversity of anogenital human papillomavirus in women attending cervical cancer screening in Harare, Zimbabwe. J Med Virol. 2017;89:1671–1677.
4. Mbiri W, Chin’ombe N. Molecular Identification of Plasmodium Species in Malaria in Zimbabwe by Mitochondrial DNA Sequencing. International Journal of TROPICAL DISEASE & Health. 2017. 21(2): 1-8.
5. Sebata NL, Chin’ombe N. Molecular Detection and Typing of Genital Human Papillomavirus among Female Medical and Nursing Students in Harare, Zimbabwe. International STD Research & Reviews. 2017. 5(1): 1-8.
6. Baudi I, Iijima S, Chin’ombe N, Mtapuri-Zinyowera S, Murakami S, Isogawa M, Hachiya A, Iwatani Y, Tanaka Y. Molecular epidemiology of co-Infection with hepatitis B virus and human immunodeficiency virus (HIV) among adult patients in Harare, Zimbabwe. Journal of Medical Virology. 2017. 89: 257-266.
7. Mandishora RSD, Christiansen IK, Chin'ombe N, Duri K, Rounge TB, Meisal R, Ambur OH, Stray-Pedersen B, Chirenje ZM. Do HIV-infected and Uninfected Women Have Different Human Papilloma Virus Genotypes Distribution: A Cross Sectional Study Carried out in Zimbabwe. AIDS Research & Human Restroviruses, 2016, 32 (Supplement 1): 280.
8. Nyazika TK, Hagen F, Machiridza T, Kutepa M, Masanganise F, Hendrick M, Boekhout T, Magombei T, Siziba T, Chin’ombe N, Mateveke K, Meis JF, Robertson VJ. Cryptococcus neoformans population diversity and clinical outcomes of HIV-associated cryptococcal meningitis patients in sub-Sahara Africa. Journal of Medical Microbiology. 2016. 65:1281-1288.
9. Chin’ombe N, Muzividzi B, Munemo E, Nziramasanga P. Molecular identification of nontuberculous mycobacteria in humans in Zimbabwe. 2016. International Journal of Infectious Diseases. 45 (Supplement 1): 169-170.
10. Matuvhunye T, Dube-Mandishora RS, Chin’ombe N, Chakafana G, Mbanga R, Zumbika, Stray-Pedersen B. Genotyping human papillomavirus in women attending cervical cancer screening clinic in Harare, Zimbabwe. 2016. British Microbiology Research Journal. 2016. 16(6): 1-9.
11. Chin’ombe N, Manjeese W, Munemo E. Molecular Detection of Mycobacterium tuberculosis Rifampicin Drug Resistance Using rpoB Gene Sequencing in Zimbabwe. British Microbiology Research Journal. 2016. 16(5): 1-6.
12. Chin’ombe N, Muzividzi B, Munemo M, Nziramasanga P. Molecular Identification of Nontuberculous Mycobacteria in Humans in Zimbabwe Using 16S Ribosequencing. The Open Microbiology Journal. 2016; 10, 3-13.
13. Matambo R, Nyandoro G, Mungofa S, Mutseyekwa FM, Ruhanya V, Mugomeri E, Chin’ombe N. Identifying factors associated with contracting typhoid during an outbreak in Harare, Zimbabwe. Journal of Contemporary Clinical Practice. 2016; 2: 9-17.
14. Kouamou V, Chin’ombe N, Matimba A, Kadzatsa W, Nyandoro G, Musarurwa C. P53 Codon 72 Polymorphism and the Risk of Cervical Cancer in Zimbabwean Women. International Journal of Tropical Disease and Health. 2016, 15(3): 1-6.
15. Matambo R, Duri C, Ruhanya V, Mungofa S, Chadambuka E, Nyandoro G, Mugomeri E, Chin’ombe N. Evaluation of a Tuberculosis Surveillance System in the Harare City Health Department in Zimbabwe. International Journal of Tropical Disease and Health. 2016, 14(4): 1-10.
16. Matambo R, Bare H, Mungofa S, Miti G, Ruhanya V, Nyandoro G, Chin’ombe N. Evaluation of the Antiretroviral Therapy Program at Wilkins Hospital in Zimbabwe. British Journal of Medicine & Medical Research. 2016; 11(4): 1-9.
17. Padya L, Chin’ombe N, Magwenzi M, Mbanga M, Nziramasanga P. Molecular identification of Mycobacterium species of public health importance in cattle in Zimbabwe by 16S rRNA gene sequencing. The Open Microbiology Journal. 2015; 9, 38-42.
18. Chin'ombe N, Munemo E, Magwenzi M, Muzividzi B, Nziramasanga N. First Cases of Mycobacterium elephantis in Zimbabwe Revealed by 16S Ribosequencing. Archives of Clinical Microbiology. 2015; 6:10.
19. Chin’ombe N, Ruhanya V. HIV/AIDS vaccines for Africa: scientific opportunities, challenges and strategies. The Pan African Medical Journal. 2015;20:386.
20. Mugomeri E, Senauoane MB, Ruhanya V, Chin’ombe N, Nyandoro G, Occurrence of HBV/HIV coinfection by laboratory values in Roma, Lesotho. GERMS. 2015;5:8-11.
21. Tarupiwa A, Tapera S, Mtapuri-Zinyowera S, Gumbo P, Ruhanya V, Gudza-Mugabe M, Majuru NX, Chin’ombe N. Evaluation of TUBEX-TF and OnSite Typhoid IgG/IgM Combo Rapid Tests to Detect Salmonella enterica serovar Typhi During a Typhoid Outbreak in, Harare Zimbabwe. BMC Research Notes. 2015:8:50.
22. Mamvura TS, Chin’ombe N, Ruhanya V, Nziramasanga P. Seroprevalence of rubella virus IgG in pregnant women in Harare, Zimbabwe. GERMS. 2015;5(2):50-52.
23. Mugomeri E, Chatanga P, Lefunyane M, Ruhanya V, Nyandoro G, Chin’ombe N. Adherence to tuberculosis infection control guidelines by nurses in Lesotho. American Journal of Infection Control. 2015, 43(7):735-738.
24. Midzi N, Mtapuri –Zinyowera S, Mutsaka MJ, Ruhanya V, Magwenzi M, Chin’ombe N, Nyandoro G, Marume A, Kumar N and Mduluza T. Impact of School Based Health Education on Knowledge, Attitude and Practice of Grade Three Primary School Children in Zimbabwe. J Community Med Health Educ. 2014, 4: 295.
25. Chin’ombe N, Sebata NL, Ruhanya V, Matarira HT. Human Papillomavirus Genotypes in Cervical Cancer and Vaccination Challenges in Zimbabwe. Infectious Agents and Cancer. Infectious Agents and Cancer. 2014, 9:16.
26. Chapman R, Bourn WR, Shephard E, Stutz H, Douglass N, Mgwebi T, Meyers A, Chin'ombe N, Williamson AL. The Use of Directed Evolution to Create a Stable and Immunogenic Recombinant BCG Expressing a Modified HIV-1 Gag Antigen. PLoS One. 2014, 9(7):e103314.
27. Mhandire K, Duri K, Kandawasvika G, Chandiwana P, Chin’ombe N, Kanyera RB, Stray-Pedersen B, Dandara C. CCR2, CX3CR1, RANTES and SDF1 genetic polymorphisms influence HIV infection in a Zimbabwean pediatric population. J Infect Dev Ctries 2014; 8(10):1313-1321.
28. Mtapuri-Zinyowera S, Ruhanya V, Midzi N, Berejena C, Chin’ombe N, Nziramasanga P, Nyandoro G, Mduluza T. Human parasitic protozoa in drinking water sources in rural Zimbabwe and their link to HIV infection. GERMS. 2014;4:86-91.
29. Chin'ombe N. Recombinant Salmonella enterica Serovar Typhimurium as a Vaccine Vector for HIV-1 Gag. Viruses. 2013, 5, 2062-2078.
30. Chin’ombe N, Lebeko M, Kgatle M. Overexpression of recombinant HIV-1 Subtype C Tat and Nef in a Salmonella vaccine vector. Pan African Medical Journal. 2013, 16:19.
31. Chin’ombe N, Ruhanya V. Recombinant Salmonella Bacteria Vectoring HIV/AIDS Vaccines. The Open Virology Journal. 2013, 7:121-126.
32. Chin’ombe N, Msengezi O, Matarira HT. Microalbuminuria in patients with chronic kidney disease at Parirenyatwa Hospital in Zimbabwe. Pan African Medical Journal. 2013, 14,39
33. Swart M, Skelton M, Wonkam A, Kannemeyer L, Chin’ombe N, Dandara D. CYP1A2, CYP2A6, CYP2B6, CYP3A4 and CYP3A5 Polymorphisms in Two Bantu-Speaking Populations from Cameroon and South Africa: Implications for Global Pharmacogenetics. Current Pharmacogenomics and Personalised Medicine 2012 10, 43-53.
34. Chin’ombe N, Chavhunduka E, Matarira HT. Seroprevalence of HBV and HCV in primary hepatocellular carcinoma patients in Zimbabwe. Infectious Agents and Cancer 2009 4:15
35. Chin'ombe N, Bourn WR, Williamson AL, Shephard EG. Oral vaccination with a recombinant Salmonella vaccine vector provokes systemic HIV-1 subtype C Gag-specific CD4+ Th1 and Th2 cell immune responses in mice. Virology Journal 2009 6:87.
36. Chin'ombe N, Bourn WR, Williamson AL, Shephard EG. An oral recombinant Salmonella enterica serovar Typhimurium mutant elicits systemic antigen-specific CD8+ T cell cytokine responses in mice. Gut Pathogens 2009 1:9.
37. Chin’ombe N, Lebeko M and Williamson A-L. Prokaryotic expression and purification of HIV-1 Subtype C Gag for use in ELISAs. International Journal of Infectious Diseases 12 (Supplement 1), 2008.
38. Kgatle M, Williamson A-L and Chin’ombe N, Expression of HIV-1 Subtype C Tat and Nef in Salmonella vaccine vector. AIDS Research and Human Retroviruses 24 (Supplement 1), 2008, 88.
39. Lebeko M, Williamson A-L and Chin’ombe N, Purification of recombinant HIV-1 Subtype C Tat and Nef expressed from Escherichia coli. AIDS Research and Human Retroviruses 24 (Supplement 1), 2008, 96.
40. Chin’ombe N, Shephard EG, Williamson A-L and Rybicki EP, Immunogenicity of HIV-1 Subtype C Gag plasmo-VLP vaccine. AIDS Research and Human Retroviruses 24 (Supplement 1), 2008, 139.
41. Matarira HT, Mujaji WB, Chin’ombe N, Mlambo T, Nyamayaro T. The contribution of ZEQAS in the practice of laboratory medicine: 1989-1999. Journal of the Association for Laboratory Automation, 4(4) 1999, 75-77.
42. Matarira H T, Chin’ombe N. Equipping a laboratory for cancer research in a developing country. Central African Journal of Medicine 44: 1998, 138-139.
43. Chin’ombe N, Matarira, H. T. Genetic engineering: The biotechnology of miracles, hopes and fears. Central African Journal of Medicine 44, 1998, 188-189.

Patented Work:

Grants & Funding (current and Past projects):

Awards & Achievements:

1. University of Zimbabwe Research Board funding: Mycobacteria Research project: 2015-2018.
2. Claude Leon Foundation Postdoctoral Fellowship, 2011-2012: University of Cape, Cape Town, Division of Human Genetics. RSA.
3. Emory-South Africa NRF Drug Discovery Post-doctoral Fellowship, 2010-11: Emory Vaccine Center, Emory University, Atlanta, USA.
4. Global HIV Vaccine Enterprise scholarship to attend 5th African AIDS Vaccine Programme (AAVP) Forum, 13-15 December, 2009, Kampala, Uganda.
5. Bill & Melinda Gates Foundation Award for registration subsidy of the Keystone Conference on Overcoming the Crisis of TB and AIDS. Arusha, Tanzania, October, 2009.
6. International Society for Infectious Diseases scholarship for registration for the 13th International Conference on Infectious Diseases Conference, Kuala Lumpur, June 2008.
7. National Research Foundation/University