Researcher Profiles

Comprehensive Database of all UZ leading Research and Innovation endeavors

Prof. Stanley Mukanganyama

Qualifications:

DPhil (Biochemistry) Uppsala University, MPhil, (Biochemistry) University of Zimbabwe, Postdoctoral studies at the Department of Chemical Pathology at the University of Cape Town,

Academic Appointments:

Full Professor and Chairperson

Research Interests:

Biochemical Pharmacology, Biochemistry


Faculty: Science
Department: Biochemistry
Research Category: Bioscience
Biography:

Professor Stanley Mukanganyama joined the University of Zimbabwe in the Department of Biochemistry as a Teaching Assistant on 01 April 1991 and enrolled as a part-time MPhil student. In 1996 he converted his studies to DPhil which he carried out as sandwich programme with Uppsala University, Sweden. He successfully completed his DPhil studies in 1999. In February 2001 he was appointed as a lecturer in the Department of Biochemistry. He was promoted to Senior Lecturer on 2 February 2008 and to the Associate Professor grade on 1 January 2013. Professor Mukanganyama served as the acting Chairperson of the Department of Biochemistry from July-November 2011. He was appointed the substantive Chairperson of the Department of Biochemistry from 1 November 2011 until present. He is the past President of the Biochemistry and Molecular Biology Society of Zimbabwe (BMBSZ) from 2010-2013, and is the In-country President of the Natural Products Research of Eastern and Central Africa (NAPRECA) Zimbabwe Chapter. Professor Mukanganyama is also the Acting Secretary-General of the Federation of the African Societies of Biochemistry and Molecular Biology (FASBMB). His area of specialisation is Biochemical Pharmacology where he is involved in the scientific evaluation and validation of efficacy of medicinal chemicals from plants from Zimbabwe.


Email: smukanganyama@medic.uz.ac.zw
Phone: +263 774 863 465
Publications:

1. Hayeshi, R, Mutingwende, I, Mavengere, W, Masiyanise, Mukanganyama, S. V. 2007.The inhibition of human glutathione S-transferases activity by plant polyphenolic compounds ellagic acid and curcumin. Food and chemical toxicology 45 (2), 286-295
2. Mukanganyama, S, Widersten, M, Naik, YS, Mannervik, B, Hasler, JA. 2002. Inhibition of glutathione S‐transferases by antimalarial drugs possible implications for circumventing anticancer drug resistance. International journal of cancer 97 (5), 700-705
3. Hayeshi, R, Masimirembwa, C, Mukanganyama, S, Ungell, ALB. 2006. The potential inhibitory effect of antiparasitic drugs and natural products on P-glycoprotein mediated efflux. European journal of pharmaceutical sciences 29 (1), 70-81
4. Mukanganyama, S, Figueroa, CC, Hasler, JA, Niemeyer, HM. 2003. Effects of DIMBOA on detoxification enzymes of the aphid Rhopalosiphum padi (Homoptera: Aphididae). Journal of Insect Physiology 49 (3), 223-229
5. Chitemerere, TA, Mukanganyama, S. 2011. In vitro antibacterial activity of selected medicinal plants from Zimbabwe. The African Journal of Plant Science and Biotechnology 5 (1), 1-7
6. Mabhiza, D., Chitemerere, T, Mukanganyama, S. 2016. Antibacterial Properties of Alkaloid Extracts from Callistemon citrinus and Vernonia adoensis against Staphylococcus aureus and Pseudomonas aeruginosa. International journal of medicinal chemistry 2016
7. Hayeshi, R., Chinyanga, F., Chengedza, S, Mukanganyama, S. 2006. Inhibition of human glutathione transferases by multidrug resistance chemomodulators in vitro. Journal of enzyme inhibition and medicinal chemistry 21 (5), 581-587
8. Hayeshi, R, Mukanganyama, S., Hazra, B, Abegaz, B, Hasler, J. 2004. The interaction of selected natural products with human recombinant glutathione transferases. Phytotherapy Research: An International Journal Devoted to Pharmacological …
9. Chitemerere, TA, Mukanganyama, S. 2014. Evaluation of cell membrane integrity as a potential antimicrobial target for plant products. BMC complementary and alternative medicine 14 (1), 278
10. Chimponda, T, Mukanganyama, S. 2010. Antimycobacterial activities of selected medicinal plants from Zimbabwe against Mycobacterium aurum and Corynebacterium glutamicum. Trop Biomed 27 (3), 595-610
11. Hayeshi, R., Masimirembwa, C, Mukanganyama, S, Ungell, ALB. Lysosomal trapping of amodiaquine: impact on transport across intestinal epithelia models. Biopharmaceutics & drug disposition 29 (6), 324-334
12. Mukanganyama, S., Naik, YS., Widersten, M., Mannervik,B., Hasler, JA. 2001. Proposed reductive metabolism of artemisinin by glutathione transferases in vitro. Free radical research 35 (4), 427-434
13. Mukanganyama, S, Bezabih, M., Robert, M., Ngadjui,BT., Kapche, GFW. 2011. The evaluation of novel natural products as inhibitors of human glutathione transferase P1-1.Journal of enzyme inhibition and medicinal chemistry 26 (4), 460-467
14. Mukanganyama, S., Ntumy, AN., Maher, F, Muzila, M, Andrae-Marobela, K. 2011. Screening for anti-infective properties of selected medicinal plants from Botswana. African Journal of Plant Science and Biotechnology 5 (1), 1-7
15. Mukanganyama, S., Masimirembwa, CM., Naik, YS, Hasler, JA. 1997. Phenotyping of the glutathione S-transferase M1 polymorphism in Zimbabweans and the effects of chloroquine on blood glutathione S-transferases M1 and A. Clinica chimica acta 265 (2), 145-155
16. Mangoyi, R., Mafukidze,W., Marobela, K., Mukanganyama, S. 2012. Antifungal activities and preliminary phytochemical investigation of Combretum species from Zimbabwe. Microbial and Biochemical Technology 4, 037-044
17. Tambama, P, Abegaz, B., Mukanganyama, S. 2014. Antiproliferative activity of the P isofuranonaphthoquinone isolated from Bulbine frutescens against jurkat T cells. BioMed research international.
Mukanganyama, S, Dumbura, SC, Mampuru, L. 2012. Anti-Proliferative Effects of Plant Extracts from Zimbabwean Medicinal Plants against Human Leukaemic Cell Lines. The African Journal of Plant Science and Biotechnology 6 (1), 14-20

Patented Work:

Grants & Funding (current and Past projects):

Awards & Achievements:

Consultancy and advisory work (current and past):

Supervision information (MPhil, DPhil, etc.):

Professional membership, Committees, Boards:

• In-country President of the Natural Products Research of Eastern and Central Africa (NAPRECA) Zimbabwe Chapter
• past President of the Biochemistry and Molecular Biology Society of Zimbabwe (BMBSZ) from 2010-2013

External Profile Links (Google Scholar, ResearchGate, LinkedIn, other social media links):

ResearchGate: https://www.researchgate.net/profile/Stanley_Mukanganyama
LinkedIn: https://www.link




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